Totally different drugs are prescribed to deal with completely different signs of gout and joint ache:
Deal with acute gout assaults and prevent future assaults
Reduce the risk of gout complications, such as the deposits of urate crystals that cause nodules to kind under the skin (tophi)
Medicine used to deal with acute attacks and prevent future attacks embody:
Nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs might control inflammation and ache in folks with gout. Your physician could prescribe the next dose to cease an acute assault, adopted by a lower day by day dose to stop future attacks.
NSAIDs embody over-the-counter choices equivalent to ibuprofen (Advil, Motrin, others) and naproxen (Aleve, others), in addition to more highly effective prescription NSAIDs comparable to indomethacin (Indocin). NSAIDs carry risks of abdomen ache, bleeding and ulcers.
Colchicine. Should you're unable to take NSAIDs, your physician could recommend colchicine, a type of ache reliever that successfully reduces gout ache - especially when began soon after symptoms appear. The drug's effectiveness is offset most often, nevertheless, by insupportable negative effects, reminiscent of nausea, vomiting and diarrhea.
After an acute gout attack resolves, your physician could prescribe a low each day dose of colchicine to prevent future attacks.
Corticosteroids. Corticosteroid medications, such because the drug prednisone, could control gout inflammation and pain. Corticosteroids may be administered in capsule kind, or they can be injected into your joint. Corticosteroids are usually reserved for people who can't take both NSAIDs or colchicine.
Uncomfortable side effects of corticosteroids might embrace thinning bones, poor wound healing and a decreased capacity to battle infection. To scale back the danger of these serious unwanted effects, your doctor will try to discover the bottom dose that controls your symptoms and prescribe steroids for the shortest attainable time.
Medication used to forestall the complications associated with frequent gout attacks include:
Treatment that blocks uric acid production. Medication known as xanthine oxidase inhibitors, including allopurinol (Zyloprim, Aloprim) and febuxostat (Uloric), limit the amount of uric acid your physique makes. This may lower your blood's uric acid degree and scale back your risk of gout. Unwanted effects of allopurinol embody a rash and low blood counts. Febuxostat uncomfortable side effects include rash, nausea and lowered liver function.
Xanthine oxidase inhibitors could trigger a brand new, acute attack if taken earlier than a recent assault has totally resolved. Taking a short course of low-dose colchicine before beginning a xanthine oxidase inhibitor has been found to considerably reduce this risk.
Treatment that improves uric acid removal. Probenecid (Probalan) improves your kidneys' potential to take away uric acid out of your body. This may lower your uric acid ranges and scale back your threat of gout, but the level of uric acid in your urine is increased. Negative effects embody a rash, stomach pain and kidney stones.
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