The pressure exerted from the blood against the walls of blood vessels is called blood pressure. 120/80 is the standard blood pressure of the ordinary adult. High blood pressure has been defined as over 140/90. Hypertension or high blood pressure is a major risk issue for the development of cardiovascular diseases, which are the leading causes of morbidity and mortality in western society. Approximately 20% of the adult populace world wide suffers from hypertension. 25% of the adult population in the United States suffers from hypertension, high blood pressure, that is a primary risk factor for heart disease and a major contributor to stroke and heart failure. High blood pressure becomes increasingly prevalent with age as arteries loose elasticity. The renin-angiotensin system (RAS) is one of several metabolic systems that influences blood pressure. This system secretes angiotesion in the kidneys which is a converting enzyme (ACE). This would typically set off blood vessel constriction as well as elevated blood pressure. Inhibitors of the ACE enzyme in blood vessels are a major class of antihypertensive medications that are prescribed to manage high blood pressure. Zestril, Capoten and Vasotec are examples of perscription medicines used to assist people with high blood pressure as they thwart the effects of ACE.
Synthetic ACE inhibitors have been known to cause many adverse side effects that include hypotension, reduced kidney function, coughing and skin rashes. There is certainly various food proteins that supply natural ACE inhibitors as well. In particular, milk proteins contain ACE inhibitory peptides (ACE-IP) which will be released by enzymatic hydrolysis either during gastrointestinal digestion or throughout food processing. The release of ACE-IP is triggered by in vitro incubation of milk proteins with the gastrointestinal proteases pepsin, trypsin, and chymotrypsin. Normal gastrointestinal digestion is when ACE-IP is created. ACE-IP is also released by bacterial and plant proteins. Therefore ACE-IP may be found in hydrolysates of milk protein, caseinates, whey proteins and fractions of enriched individual milk proteins.
Diet:
A diet referred to as Dietary Approaches to Stop Hypertension (DASH) is currently recommended as an important step in managing blood pressure. This diet is not only rich in important nutrients and fiber however also includes foods that contain a lot more electrolytes, potassium, calcium, and magnesium. The DASH diet suggests to:
- Avoid saturated fat (though include calcium-rich dairy products that are non- or low-fat).
- When selecting fats, select monounsaturated oils, like olive or canola oils. (It has been reported that folks with a high intake of virgin olive oil as opposed to sunflower oil (a polyunsaturated fat) had a reduced requirement for anti-hypertension medicinal drugs.)
- Whole grains are better choices over white flour or pasta products.
- Every day one should consume fresh fruits and vegetables. Several of those foods are rich in fiber, that may help lower blood pressure Potassium abundant fruits like bananas, oranges, prunes, and cantaloupes as well as vegetables like carrots, spinach, celery, alfalfa, mushrooms, lima beans, potatoes, avocados, and broccoli are all considered necessary daily foods.
- Protein needs to be taken in modest quantities.
Therefore for individuals with high blood pressure the proteins that are vital for bodybuilding and synthesizing enzymes are imperative. Blood pressure may also be lowered by both whey and casein (milk proteins).
Whey protein:
Lactokinins are peptides that come from the milk protein whey. Whey contains about 20% of original milk proteins. 18% of cow milk and 67% of human milk is whey protein (lactalbumin) and respectively casein constitutes 82% of cow milk and 33% of human milk. These have recently been shown to be mild ACE inhibitors in vitro. Natural occuring proteins that aid in lowering blood pressure still are not comparable to the full fledged perscriptions but they do have the benefit of being all natural. Latest data additionally suggests that whey protein hydrolysates lead to reductions of systolic blood pressure (a transient pressure peak when the heart is contracting and forcing blood through the arterial system) and diastolic blood pressure (the sustaining pressure within the arterial system when the heart is filling with blood). Also, no side effects are reported concerning these proteins. Whey protein is soluble, easy to digest and is efficiently absorbed into the body.
Casein protein:
Caseins are a family of phosphoproteins synthesized in the mammary gland. Biologically active peptides are easily absorbed with the intake of caseins, which also safeguards activity in the body. Various rat studies demonstrate the hypotensive effects of milk-derived ACE-IP. However, only a limited number of human studies have been conducted to date. In hypertensive subjects both systolic and diastolic blood pressure were reduced with just 20g/day of a tryptic hydrolysate of casein. More recently, a tryptic hydrolysate of casein containing specific residues of as1-casein peptide could additionally reduce blood pressure in hypertensive subjects.
The management of high blood pressure is becoming less taxing because of the studies regarding the beneficial function of diary protein peptides. This really is good news to people with high blood pressure for the reason that they are now in a position to meet their protein requirements and bring down their blood pressure with the use of whey and casein. Individuals with high blood pressure ought to consult their physician about these milk protein supplements to be included in their diets.
3. V. Vermeirssen, J. Van Camp, K. Decroos, L. Van Wijmelbeke & W. Verstraete (2003). The impact of fermentation and in vitro digestion on the formation of ACE inhibitory activity from pea and whey protein. Journal of Dairy Science, 86(2), 429-438.
4. V. Vermeirssen, B. Deplancke, K.A. Tappenden, J. Van Camp, H.R. Gaskins & W. Verstraete (2002). Intestinal transport of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg through a Caco-2 Bbe monolayer. Journal of Peptide Science, 8(3), 95-100.
Author Resource:
About Protica Research
Founded in 2001, Protica Research (Protica, Inc.) is a nutritional research firm specializing in the development of capsulized foods (dense nutrition in compact liquid and food forms). Protica manufactures Profect (www.profect.com), IsoMetric, Pediagro, Fruitasia and more than 100 other brands in its GMP-certified, 250,000 square foot facility. One area of specialty is the manufacturing of Medicare-approved, whey protein shots for immunodeficiency patients.
You can learn more about Protica at www.protica.com - Copyright - Protica Research
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